Ditto everyone else. It will work just fine on the 622. Takes a bit of time to tweak and get set up, but it is well worth the time spent to do it.
nice thing about the 360 harmony remote is that it has the 4 colored buttons that match the 360's buttons. but for the DVR i use those buttons for the DVR, GUIDE, ZOOM, and TV ZOOM buttons. no figitting with the menu (at the top of the remote) 99% of the time.There is no "DVR" button, and last I checked there is no way to program one in, so you have to go thru the Menu function to get to the My Recordings.