Yes, as I've said, there are several issues that can arise, and consistency is a big one.
I just did a 625/322, backfed the TV2's via diplexers and a reversed splitter, then ran then to a good spot to split it 3 ways for 3 bedrooms.
One of the BR feeds was 75' of good dual RG-6 - the other side was for a cable modem.
First, I tried to use the default of channel 60 for the 625 - lousy picture. Changed to Channel 35 - great picture. Why? Think of all the loss from diplexers cable and splitters. Put the 322 on channel 40 - A-OK.
Started auto-programming TVs around the house, and got several VHF & UHF channels. Most were unwatchable, but a few had good quality (nice bonus for the customer). They were NOT OTA (channel numbers didn't match up), but there solely due to the 75' of dual RG-6 between the cable modem and the 3-way splitter causing bleedover - AND the cable signal passed through the 3-way in all directions.
For this case, the flaws were a GOOD thing, but it gives you an idea of how messy it can get.