This is my advice too. A buddy has an older one he bought 5 or 6 years ago. At first I thought I wanted one too. After he got his I tried it out and while he loves it I for some reason just couldn't get used to it and having to do something on screen. I don't know why, but it just didn't fit me. I ended up glad I didn't order one, especially considering the price. He loves his though and most people seem to love theirs so I must just be the oddball. His does work great though and controls everything he has.They are great remotes. My only word of caution would be to actually see and hold one before simply ordering it. Make sure it is comfortable for you and make sure that you eill like the layout of buttons etc. you can make any button perform any command but some are dissatisfied with some models because the labeled keys are not convenient for them or because they don't like using some of the on screen command.
Overall they are great. the Harmony One seems the most convenient of the lot but everyone has different tastes.