I have all my receivers (a 322 & 2/522's) centrally located and I'm using the RF out's to feed the TV's throughout my home, and I must say that the picture is EXCELLENT with these new receivers. The only one I don't use RF on is my 921 wich is located at my HDTV. Unless they will be large screen tv's or HDTV's, I think you'll be fine using the RF outouts. This also gives you the option of using modulators to distribute other sourced throughout your home such as DVD's, surveillance cameras etc. Even if you eventually have 12 TV's ( alas, I only have 9

) you shouldn't need 12 receivers. You really only need as many receivers as the number of people in your house .
The whole idea of having your house wired such as yours, with all the wires home-run to a hub (mine is wired the same way) is to have all your equipment centrally located and then distributed out to the rest of the house including; satellite or cable, computer network, telephone, whole house audio, security cameras, lighting & home automation .
Did you also wire for whole house audio ?