Of course. I will bet there will be something that will change the way technology works all together.
And we see it happening already: Cloud Computing is a good example. Pretty soon all computers (and most of the gadgets) will be connected to the Internet all the time and at a very high speed. Who needs a powerful CPU in a computer or a tablet if most of the CPU-intensive tasks can be outsourced to the Cloud?!
I wouldn't worry about Moore's low bumping into the silicone density, or something. It will find a way and the computational power will continue to grow exponentially.
Look at what happened with modems for example: modem speed grew according to Moore's law: 600 baud, 1200, 2400, 4800, and so on, doubling every couple of years or so until it reached the 56K limit set by the phone lines. And suddenly the modem speed growth stopped. So, what happened to the Moore's law? It found another way! DSL and cable modems emerged and saved the Moore's law! The Internet speed continues to grow in spite of the limitations presented by phone lines. The same will happen with computers.
Another example: CPU's have pretty much reached their maximum clock rate, which until recently grew exponentially too. What happened then? Instead of increasing the clock rate, chip manufacturers started to multiply cores...