I use a Harmony 880 with my ViP622, a JVC receiver, a JVC DVD 7 disc player, a JVC HDTV, and at times, LG & Sony equipment.
It works great. It's the only remote I need. You program it online by listing your equipment. Very simple. I went thru several cheaper remotes that never did get fully programmed. I should have bought the 880 first.