I wouldn't think it's that big a difference because even if the Sox open on the road against the Angels, the Sox OWN the Angels in the playoffs so I don't think it would be that big a deal. If the Red Sox beat the Angels, than, I think, the Sox will coast to the World Series.
Point taken but three things:
1. The Angels owned the Red Sox this year, winning the season series 8-1
2. IMO, the Angels are the best team in baseball this year
3. I don't care who I'm playing, I'd much rather play at home (especially vs. flying across the country).