First I was just playing it naturally until I beat the game on experienced difficulty. After that I took a look at the trophy list and thought the remaining trophies looked doable. Then I played specifically to get the rest of the trophies. The one that gave me the most trouble was playing through the entire game on experienced without losing your 3 lives. Beating the game on veteran was tough but you could do it one level at a time so dying in the 3rd level didn't mean you have to start over. Beating a level on master difficulty was also tough but thankfully you only have to beat one level on that difficulty. I don't think I could beat the whole game on master.